bias-detection

Research

Assess systematic biases in the evidence body — publication bias, reporting bias, and selective outcome reporting. Budget: 40 studies, 40 effect sizes, 40 web searches.

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Bias Detection Strategy

Design a protocol to systematically assess biases that threaten the validity of meta-analytic conclusions.

Purpose

Bias in the evidence body (publication bias, outcome reporting bias, citation bias, time-lag bias, language bias) can invalidate pooled estimates. This strategy designs the complete bias detection and adjustment protocol — funnel plots, statistical tests, sensitivity analyses, and GRADE certainty downgrading.

Budget

Resource	Floor	Target
Studies identified	28	40
Effect sizes extracted	28	40
Web searches	28	40
Bias domains assessed	5	8
Quality assessments	20	40

Budget gate: cannot exit until 80% of floor met.

State Ledger

<HARD-GATE>
| Metric | Current | Floor | Target | Status |
|--------|---------|-------|--------|--------|
| Studies found | 0 | 28 | 40 | BLOCKED |
| Effect sizes planned | 0 | 28 | 40 | BLOCKED |
| Web searches done | 0 | 28 | 40 | BLOCKED |
| Bias domains assessed | 0 | 5 | 8 | BLOCKED |
| Quality assessed | 0 | 20 | 40 | BLOCKED |
</HARD-GATE>

Available Tactics

Tactic	When to Use
effect-size-extraction	Extract effect sizes with precision (SE, CI)
quality-assessment-protocol	Full RoB2 assessment per study
evidence-synthesis-planning	Plan bias-adjusted models

Available SOPs

SOP	When to Use
pico-formulation	Frame the evidence assessment question
inclusion-criteria-design	Include grey literature, preprints
effect-size-planning	Ensure precision metrics extracted
data-extraction-form	Template capturing reporting completeness
risk-of-bias-assessment	Per-study RoB (core of this strategy)
publication-bias-assessment	Core SOP — funnel plots, statistical tests
sensitivity-analysis-design	Trim-and-fill, selection models
heterogeneity-source-analysis	Bias as heterogeneity driver
meta-analysis-synthesis	Final bias assessment protocol

Execution Guidance

Frame — Run pico-formulation for the evidence reliability question
Scope — Run inclusion-criteria-design maximizing source diversity (grey lit, preprints, registries)
Search — Search for published AND unpublished studies, trial registries
Extract — Use effect-size-extraction with precision metrics (SE, CI, N)
Assess — Use quality-assessment-protocol for comprehensive RoB2
Detect — Run publication-bias-assessment for statistical detection plan
Investigate — Run heterogeneity-source-analysis for bias-driven heterogeneity
Adjust — Run sensitivity-analysis-design for bias-adjustment methods
Synthesize — Run meta-analysis-synthesis for final protocol

Web searches target: trial registries, grey literature databases, dissertation repositories, conference abstracts.

Output Format

protocol:
  question: [Is the evidence body for X biased?]
  bias_domains:
    publication_bias:
      visual: [funnel plot, contour-enhanced funnel]
      statistical: [Egger's test, Begg's test, Peters' test]
      adjustment: [trim-and-fill, Copas selection model, PET-PEESE]
    outcome_reporting_bias:
      detection: [registry-publication comparison]
      tool: [ROB-ME, ORBIT]
    time_lag_bias:
      detection: [time-to-publication analysis]
    citation_bias:
      detection: [citation network analysis]
    language_bias:
      mitigation: [multi-language search strategy]
    small_study_effects:
      detection: [funnel asymmetry, regression tests]
      adjustment: [limit meta-analysis]
  grey_literature_search: [databases, registries, contacts]
  grade_assessment:
    domain: publication_bias
    downgrading_criteria: [when to downgrade certainty]
  sensitivity_plan: [selection model, 3PSM, p-curve, z-curve]
  reporting: PRISMA-2020 + ROB-ME guidelines

Available Tactics

Optional, no fixed order; the final leaf is always a sop.

Tactic	When to use
effect-size-extraction	Systematically extract effect sizes and conditions from papers for meta-analytic synthesis
evidence-synthesis-planning	Plan the statistical synthesis approach — model selection, heterogeneity strategy, and reporting
quality-assessment-protocol	Methodological quality and bias risk assessment of included studies using validated tools

Available SOPs

Optional, no fixed order; the final leaf is always a sop.

SOP	When to use
data-extraction-form	Design structured data extraction form for systematic meta-analysis data collection
effect-size-planning	Determine effect size types and calculation methods for meta-analytic synthesis
heterogeneity-source-analysis	Identify and classify sources of between-study heterogeneity (clinical, methodological, statistical)
inclusion-criteria-design	Define inclusion/exclusion criteria for systematic study selection in meta-analysis
meta-analysis-synthesis	Produce final meta-analysis protocol document assembling all planning outputs into PRISMA-compliant protocol
pico-formulation	Construct PICO/PECO framework for the meta-analysis research question
publication-bias-assessment	Plan funnel plots, Egger's test, trim-and-fill, p-curve, and selection model analyses for publication bias
risk-of-bias-assessment	Assess methodological bias using RoB2, PROBAST, or QUADAS-2 validated tools
sensitivity-analysis-design	Design leave-one-out, influence diagnostics, subgroup analyses, and robustness checks