Research skills

Browse reusable Agent Skills, each with a clear purpose and practical guidance.

ukb-navigator

Semantic search across UK Biobank's 12,000+ data fields and publications — find the right variables for your research question.

2.85k repo starsObserved in 9 repos
Research

bio-differential-expression-timeseries-de

Analyze time-series RNA-seq data using limma voom with splines, maSigPro, and ImpulseDE2. Identify genes with dynamic expression patterns. Use when analyzing time-series or longitudinal expression data.

2.85k repo starsObserved in 7 repos
Research

bulk-wgcna-analysis-with-omicverse

Assist Claude in running PyWGCNA through omicverse—preprocessing expression matrices, constructing co-expression modules, visualising eigengenes, and extracting hub genes.

2.85k repo starsObserved in 7 repos
Research

bio-clinical-databases-gnomad-frequencies

Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.

2.85k repo starsObserved in 6 repos
Research

bio-methylation-dmr-detection

Differentially methylated region (DMR) detection using methylKit tiles, bsseq BSmooth, and DMRcate. Use when identifying contiguous genomic regions with methylation differences between experimental conditions or cell types.

2.85k repo starsObserved in 6 repos
Research

bio-clinical-databases-dbsnp-queries

Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.

2.85k repo starsObserved in 5 repos
Research

bio-hi-c-analysis-hic-differential

Compare Hi-C contact matrices between conditions to identify differential chromatin interactions. Compute log2 fold changes, statistical significance, and visualize differential contact maps. Use when comparing Hi-C contacts between conditions.

2.85k repo starsObserved in 5 repos
Research

clinpgx

Query the ClinPGx API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels

2.85k repo starsObserved in 5 repos
Research

bio-isoform-switching

Analyzes isoform switching events and functional consequences using IsoformSwitchAnalyzeR. Predicts protein domain changes, NMD sensitivity, ORF alterations, and coding potential shifts between conditions. Use when investigating how splicing changes affect protein function.

2.85k repo starsObserved in 4 repos
Research