Research skills

Browse reusable Agent Skills, each with a clear purpose and practical guidance.

cross-disease-shared-biomarker-network-research-planner

Generates complete cross-disease shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Always use this skill whenever a user wants to design, plan, or build a multi-dataset study linking two related diseases through shared DEGs, enrichment, PPI hub genes, public validation, regulatory-network analysis, immune infiltration, drug-gene interaction screening, and optional qRT-PCR or cell-line validation. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, regulatory-network interpretation, immune/drug follow-up, bioinformatics-plus-validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.

1.45k repo starsObserved in 2 repos

Research

GitHub

crossref-database

Access CrossRef metadata for scholarly works; use when you need to resolve a DOI or search CrossRef to retrieve bibliographic details, citation/reference counts, or funder information for research and citation management.

1.45k repo starsObserved in 2 repos

Research

GitHub

ctd-api

Accesses Comparative Toxicogenomics Database (CTD) for chemical, gene, disease, and pathway interaction data. Invoke when user needs to query CTD, retrieve toxicogenomics data, or investigate chemical-disease relationships.

1.45k repo starsObserved in 2 repos

Research

GitHub

diagnostic-study-quality-assessment-quadas

Analyzes clinical diagnostic accuracy studies for bias using the QUADAS-2 tool. Use when Claude needs to assess the quality, risk of bias, or applicability of diagnostic accuracy studies (e.g., "Assess this paper using QUADAS-2").

1.45k repo starsObserved in 2 repos

Research

GitHub

diagnostic-study-quality-assessment-quadas-2

1.45k repo starsObserved in 2 repos

Research

GitHub

disease-mechanism-evidence-map

Systematically maps mechanism evidence for a disease from molecules to pathways, cell types, tissues, biological consequences, and clinical phenotypes. Always use this skill when a user needs a layered mechanism evidence chain rather than a flat summary or immediate gap analysis. Formal literature citations must be real and verifiable.

1.45k repo starsObserved in 2 repos

Research

GitHub

drug-repurposing-study-planner

Design evidence-discovery and validation workflows for drug repurposing studies by integrating disease mechanisms, drug-target logic, expression reversal, real-world evidence, and validation routes into a closed-loop study blueprint.

1.45k repo starsObserved in 2 repos

Research

GitHub

drug-target-evidence-landscape

Organizes the evidence and competitive landscape around a drug, target, or pathway by separating disease relevance, tractability, preclinical evidence, clinical evidence, modality fit, and crowding. Always map what is biologically supported, what is druggable, what has actually advanced, and what remains strategically open. Never confuse target relevance with druggability, preclinical activity with clinical promise, or narrative excitement with validated development maturity. Never fabricate references, trial status, approval status, company activity, or asset metadata.

1.45k repo starsObserved in 2 repos

Research

GitHub

drugbank-database

Programmatic access to DrugBank drug and target data; use when you need to download, parse, and analyze DrugBank XML for properties, interactions, pathways, and pharmacology.

1.45k repo starsObserved in 2 repos

Research

GitHub

dual-disease-shared-transcriptome-biomarker-research-planner

Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...

1.45k repo starsObserved in 2 repos

Research

GitHub