Solublempnn
OtherssolublempnnSolublempnn is an Agent Skill for general use published in the companion-inc/feynman repository on GitHub: a SKILL.md instruction file an AI agent can load to do this task.
Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering.
QUICK START
How to use this skill
Bring this guide into your coding agent with a prompt tailored to the tool you use.
- Open your project in Codex.
- Copy and paste the prompt below.
- Review files and risks before approving any action.
Prompt to paste
Inspect the Agent Skill at https://github.com/companion-inc/feynman/blob/HEAD/skills/solublempnn/SKILL.md and all supporting files. Report provenance, permissions, scripts, dependencies, and security risks. Propose an exact installation into .agents/skills/solublempnn, but wait for my approval before writing files or running scripts.
Copying this prompt does not install or run the skill. Review third-party files before use.
SolubleMPNN
Use this skill for solubility-aware protein design.
Workflow:
- Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
- Verify model availability and execution path before running.
- Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
- Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
- Attach assay or expression-screen recommendations when a decision depends on solubility.
Do not equate a solubility score with confirmed expression.